Simulated Microgravity Impairs Cardiac Autonomic Neurogenesis from Neural Crest Cells
نویسندگان
چکیده
منابع مشابه
Transient Notch Activation Initiates an Irreversible Switch from Neurogenesis to Gliogenesis by Neural Crest Stem Cells
The genesis of vertebrate peripheral ganglia poses the problem of how multipotent neural crest stem cells (NCSCs) can sequentially generate neurons and then glia in a local environment containing strong instructive neurogenic factors, such as BMP2. Here we show that Notch ligands, which are normally expressed on differentiating neuroblasts, can inhibit neurogenesis in NCSCs in a manner that is ...
متن کاملMigration of cardiac neural crest cells in Splotch embryos.
Pax3 encodes a transcription factor expressed during mid-gestation in the region of the dorsal neural tube that gives rise to migrating neural crest populations. In the absence of Pax3, both humans and mice develop with neural crest defects. Homozygous Splotch embryos that lack Pax3 die by embryonic day 13.5 with cardiac defects that resemble those induced by neural crest ablation in chick mode...
متن کاملMisregulation of SDF1-CXCR4 signaling impairs early cardiac neural crest cell migration leading to conotruncal defects.
RATIONALE Cardiac neural crest cells (NCs) contribute to heart morphogenesis by giving rise to a variety of cell types from mesenchyme of the outflow tract, ventricular septum, and semilunar valves to neurons of the cardiac ganglia and smooth muscles of the great arteries. Failure in cardiac NC development results in outflow and ventricular septation defects commonly observed in congenital hear...
متن کاملNodose placode contributes autonomic neurons to the heart in the absence of cardiac neural crest.
The objective of this research was to determine the origin of the cholinergic neurons that populate the heart following ablation of the neural crest area, which normally gives rise to the cardiac ganglia. Using ablation of various areas of surface ectoderm--including neural crest migrating to the heart, nodose placode, and neural crest plus nodose placode--it was determined that regeneration of...
متن کاملEvidence for increased cardiac compliance during exposure to simulated microgravity.
We measured hemodynamic responses during 4 days of head-down tilt (HDT) and during graded lower body negative pressure (LBNP) in invasively instrumented rhesus monkeys to test the hypotheses that exposure to simulated microgravity increases cardiac compliance and that decreased stroke volume, cardiac output, and orthostatic tolerance are associated with reduced left ventricular peak dP/d t. Six...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Stem Cells and Development
سال: 2018
ISSN: 1547-3287,1557-8534
DOI: 10.1089/scd.2017.0265